Iron Homeostasis in the Lung Following Asbestos Exposure
That asbestos exposure causes multiple pulmonary diseases has been conclusively known since at least the 1920s. What have remained in question are the physiological mechanisms by which exposure leads to disease and/or death. Researches from the EPA have recently studied the relationship between asbestos and iron homeostasis and have determined that one of the mechanisms by which asbestos causes disease is through disruption of processes involved in iron homeostasis. Using bronchoalveolar lavage, the researches compared the lung condition of workers with known exposure to asbestos to those without known exposures and have proposed a descriptive model of how oxidant stress causes lung injuries after exposure to asbestos.