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Current Trials for MesotheliomaThe following clinical trials for mesothelioma are currently seeking participants as of April 2009. The studies are sorted by their relevance to malignant mesothelioma. For more information on these or other clinical trials in progress, click here. Cisplatin, Pemetrexed, and Imatinib Mesylate in Malignant Mesothelioma Condition: Mesothelioma Interventions: Drug: Cisplatin; Drug: Imatinib Mesylate; Drug: Pemetrexed Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma Conditions: Malignant Mesothelioma; Metastatic Cancer Interventions: Other: talc; Procedure: therapeutic thoracoscopic surgery; Procedure: therapeutic thoracoscopy; Procedure: therapeutic videothoracoscopy Dasatinib in Resectable Malignant Pleural Mesothelioma Condition: Malignant Pleural Mesothelioma Intervention: Drug: Dasatinib Immunotoxin Therapy, Pemetrexed, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed by Surgery Condition: Malignant Mesothelioma Interventions: Biological: SS1(dsFv)-PE38 immunotoxin; Drug: cisplatin; Drug: pemetrexed disodium; Other: immunoenzyme technique; Other: immunohistochemistry staining method; Other: pharmacological study; Procedure: quality-of-life assessment Extrapleural Pneumonectomy /Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural Mesothelioma Condition: Malignant Pleural Mesothelioma Interventions: Procedure: Extrapleural pneumonectomy (EPP), Pleurectomy/Decortication; Drug: cisplatin; Drug: gemcitabine; Drug: amifostine; Drug: sodium thiosulfate Study of CBP501 + Pemetrexed + Cisplatin in Patients With Solid Tumors (Phase I) and Patients With Malignant Pleural Mesothelioma (Phase II) Conditions: Malignant Pleural Mesothelioma; MPM; Solid Tumors Interventions: Drug: pemetrexed, cisplatin and CBP501; Drug: pemetrexed and cisplatin Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers Conditions: Lung Cancer; Mesothelioma Intervention: Observational study Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma Condition: Malignant Mesothelioma Interventions: Drug: dasatinib; Other: immunoenzyme technique; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis Tomotherapy Treatment for Mesothelioma Condition: Mesothelioma Intervention: Procedure: Tomotherapy Bortezomib in Treating Patients With Malignant Pleural Mesothelioma Condition: Malignant Mesothelioma Interventions: Drug: bortezomib; Procedure: quality-of-life assessment AZD2171 in Treating Patients With Malignant Mesothelioma That Cannot Be Removed By Surgery Condition: Malignant Mesothelioma Interventions: Drug: cediranib maleate; Other: laboratory biomarker analysis Bortezomib and Cisplatin as First-Line Therapy in Treating Patients With Malignant Mesothelioma Condition: Malignant Mesothelioma Interventions: Drug: bortezomib; Drug: cisplatin Pemetrexed Disodium and Cisplatin Followed by Surgery With or Without Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma Condition: Malignant Mesothelioma Interventions: Drug: cisplatin; Drug: pemetrexed disodium; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy Antineoplaston Therapy in Treating Patients With Advanced Mesothelioma Condition: Malignant Mesothelioma Interventions: Drug: antineoplaston A10; Drug: antineoplaston AS2-1 Dendritic Cell-Based Immunotherapy in Mesothelioma Condition: Malignant Pleural Mesothelioma Intervention: Biological: tumor lysate-loaded autologous dendritic cells Sunitinib in Treating Patients With Advanced Malignant Pleural Mesothelioma Condition: Malignant Mesothelioma Intervention: Drug: sunitinib malate Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery Condition: Malignant Mesothelioma Interventions: Drug: chemotherapy; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy Pemetrexed, Cisplatin, and Vitamin B12 in Treating Patients With Mesothelioma of the Chest That Cannot Be Removed by Surgery Condition: Malignant Mesothelioma Interventions: Dietary Supplement: vitamin B12; Drug: cisplatin; Drug: pemetrexed disodium; Genetic: gene expression analysis; Other: laboratory biomarker analysis; Other: pharmacological study Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery Condition: Malignant Mesothelioma Intervention: Drug: everolimus Study of Patients With Non-Small Cell Lung Cancer, Esophageal Cancer, Malignant Pleural Mesothelioma, Mediastinal or Chest Wall Neoplasms, or Lung Metastases From Cancers of Non-Thoracic Origin Conditions: Esophageal Cancer; Lung Cancer; Malignant Mesothelioma; Metastatic Cancer Interventions: Genetic: DNA methylation analysis; Genetic: gene expression analysis; Procedure: bronchoscopy; Procedure: endoscopic biopsy; Procedure: needle biopsy Cisplatin, Pemetrexed and Bevacizumab for Untreated Malignant Mesothelioma Condition: Mesothelioma Interventions: Drug: bevacizumab; Drug: cisplatin; Drug: pemetrexed An Efficacy Study of Milataxel (TL139) Administered Orally for Malignant Mesothelioma Condition: Mesothelioma Intervention: Drug: Milataxel Eloxatin® Plus Gemcitabine Chemotherapy for Mesothelioma Condition: Mesothelioma Intervention: Drug: Oxaliplatin/Gemcitabine An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma Condition: Mesothelioma Interventions: Drug: Vinorelbine; Drug: Vandetanib Suberoylanilide Hydroxamic Acid (SAHA) Versus Placebo in Advanced Malignant Pleural Mesothelioma Conditions: Mesothelioma; Lung Cancer Interventions: Drug: Comparator: Suberoylanilide Hydroxamic Acid (SAHA); Drug: Comparator: Placebo Study of Carboplatin and Vinorelbine in Malignant Pleural Mesothelioma Condition: Malignant Pleural Mesothelioma Intervention: Drug: Carboplatin and Vinorelbine Study Using Chemotherapy Followed by Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced But Unresectable Malignant Pleural Mesothelioma Condition: Mesothelioma Intervention: Other: Pemetrexed + Cisplatin and Intensity Modulated Radiation Therapy Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma Conditions: Carcinoma, Non-Small-Cell Lung; Mesothelioma Intervention: Drug: LBH 589 Sorafenib in Previously Treated Malignant Mesothelioma Condition: Mesothelioma Intervention: Drug: Sorafenib An Efficacy Study of MORAb-009 in Subjects With Pleural Mesothelioma Condition: Malignant Pleural Mesothelioma Intervention: Drug: MORAb-009 by IV on Days 1 and 8 every 21 days for 6 cycles. Phase II Study of Bevacizumab, Pemetrexed and Carboplatin as First-Line Therapy in Malignant Pleural Mesothelioma Condition: Mesothelioma Intervention: Drug: Bevacizumab, Pemetrexed, Carboplatin Trimodal Lung-Sparing Treatment of Pleural Mesothelioma Condition: Pleural Mesothelioma Interventions: Drug: Doxorubicin and cisplatin (intrapleural) + cisplatin and pemetrexed (systemic); Drug: Cisplatin and doxorubicin (intrapleural) Decitabine and FR901228 in Treating Patients With Advanced Lung Cancer, Esophageal Cancer, Pleural Mesothelioma, or Lung Metastases Conditions: Esophageal Cancer; Lung Cancer; Malignant Mesothelioma; Metastatic Cancer Interventions: Drug: celecoxib; Drug: decitabine; Drug: romidepsin Mesothelioma Avastin Plus Pemetrexed-Cisplatin Study Condition: Mesothelioma Interventions: Drug: Standard Chemotherapy (Pemetrexed and Cisplatin); Drug: Standard Chemotherapy (Pemetrexed and Cisplatin) + Bevacizumab Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide Conditions: Soft Tissue Sarcoma; Mesothelioma Intervention: Drug: Azacitidine In Combination With Temozolomide Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate Conditions: Pleural Mesothelioma; Malignant Pleural Mesothelioma Interventions: Drug: Cisplatin; Drug: Sodium Thiosulfate; Drug: ALIMTA Carboplatin, Bevacizumab and Pemetrexed in the First-Line Treatment of Patients With MPM Condition: Mesothelioma Intervention: Drug: Carboplatin, Bevacizumab and Pemetrexed Short Neoadjuvant Hemithoracic IMRT for MPM Condition: Malignant Pleural Mesothelioma Intervention: Other: Pre-op RT +/- chemotherapy Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors Conditions: Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Lung Cancer; Malignant Mesothelioma; Pancreatic Cancer; Prostate Cancer; Sarcoma Interventions: Drug: cisplatin; Drug: pemetrexed disodium; Drug: sorafenib tosylate FR901228 and Flavopiridol in Treating Patients With Advanced Lung, Esophageal, or Pleural Cancer Conditions: Esophageal Cancer; Lung Cancer; Malignant Mesothelioma; Metastatic Cancer Interventions: Drug: alvocidib; Drug: romidepsin Optical Coherence Tomography of the Airway in Detecting Abnormal Cells in Patients Undergoing Surgery for Lung Cancer or Lung Disease Conditions: Lung Cancer; Malignant Mesothelioma; Metastatic Cancer; Precancerous/Nonmalignant Condition Interventions: Procedure: bronchoscopic and lung imaging studies; Procedure: diagnostic bronchoscopy; Procedure: histopathologic examination; Procedure: optical coherence tomography Gene Therapy for Pleural Malignancies Conditions: Pleural Mesothelioma; Metastatic Pleural Effusions Intervention: Gene Transfer: BG00001 (adenoviral-mediated interferon-beta) A Study To Find The Best Dose Of SU011248 When Given With Pemetrexed, Pemetrexed And Cisplatin Or Pemetrexed And Carboplatin In Patients With Advanced Solid Tumors Conditions: Mesothelioma; Non-Small Cell Lung Cancer; Neoplasms Intervention: Drug: Sunitinib, Pemetrexed, Cisplatin, Carboplatin Surgery Plus Intraoperative Peritoneal Hyperthermic Chemotherapy (IPHC) to Treat Peritoneal Carcinomatosis Conditions: Stomach Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis; Mesothelioma Interventions: Procedure: cytoreductive surgery; Procedure: intraoperative peritoneal hyperthermic chemotherapy with cisplatin and mitomycin Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Condition: Cancer Interventions: Drug: fentanyl sublingual spray; Other: questionnaire administration Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Conditions: Solid Tumor; Lymphoma Intervention: Drug: belinostat Electronic Tool to Record Cancer Symptoms in Patients With Advanced Cancer Receiving Palliative Care Condition: Cancer Interventions: Other: counseling intervention; Procedure: cognitive assessment; Procedure: fatigue assessment and management; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment Phase I Study of OSI-930 and Erlotinib in Cancer Tumors Condition: Advanced Solid Tumors Intervention: Drug: OSI-930 and erlotinib 1-Methyl-d-Tryptophan in Treating Patients With Relapsed or Refractory Solid Tumors Condition: Cancer Interventions: Drug: 1-methyl-d-tryptophan; Other: flow cytometry; Other: fluorescence activated cell sorting; Other: high performance liquid chromatography; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Conditions: Ovarian Neoplasms; Colorectal Neoplasms; Melanoma; Small Cell Lung Cancer; Liposarcoma Interventions: Radiation: Ionizing radiation (IR) therapy; Radiation: Ionizing radiation (IR) Study of Pemetrexed and Bevacizumab in Patients With Head and Neck Cancer Condition: Cancer Interventions: Drug: Pemetrexed; Drug: Bevacizumab Study of Pemetrexed for Second-Line Pancreas Cancer Condition: Pancreas Cancer Intervention: Drug: pemetrexed Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer Conditions: Peritoneal Neoplasms; Retroperitoneal Neoplasms; Gastrointestinal Neoplasms; Adenocarcinoma; Neuroblastoma; Ovarian Neoplasms; Sarcoma; Adrenocortical Carcinoma; Wilms Tumor; Rhabdomyosarcoma; Desmoplastic Small Round Cell Tumor Interventions: Drug: CHPP of Cisplatin; Procedure: Abdominal Surge |
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