Receptor Epha2 Activation with Ephrina1 Suppresses Growth of Malignant Mesothelioma
A recent study has uncovered a possible new way to suppress the growth of malignant mesothelioma cells. The study attempted to uncover the mechanisms of activation of receptor EphA2 by its ligand ephrinA1 in the development of malignant mesothelioma. Activation of receptor EphA2 by its ligand ephrinA1 was shown to trigger both the phosphorylation of EphA2 and the phosphorylation of ERK1/2, which significantly decreased MMC proliferation. These studies suggest that EphA2 activation by its ligand ephrinA1 transmits intracellular signals from cell membrane to nucleus via ERK1/2 signaling cascade and inhibits MM growth.