Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration
Source: Molecular Cancer Therapeutics
This abstract describes the development of a potentially new treatment modality for malignant pleural mesothelioma. Tyrosine kinase c-Src has been shown to be have significant effects on the growth of cancer cells, so researchers looked at what effect the inhibition of c-Src would have on these cells and the initial results have been promising. To the extent that the researchers were able to inhibit c-Src, they were able to arrest the cell growth cycle and trigger apoptosis in the cancer cells. They also found that where c-Src was activated and highly expressed, the cancer cells were not only active and growing, but were likely to migrate and metastasize to distant locations. Thus, the researches have concluded that inhibition of c-Src expression could be an important treatment strategy for mesothelioma.